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Clinical Benefits LifeCycle Pharma's application of its proprietary MeltDose technology to poorly water-soluble drugs offers several clinical benefits: Decreased inter- and intra-individual variability For some substances, the therapeutic window is very narrow and minimal variability is mandatory. Reduction in the intra-subject variability will improve the efficacy and reduce the incidence of side effects. Furthermore, a decrease in the inter-subject variability will improve the dosing schedule and reduce the need for individual titration and/or physician monitoring. Reduction of fed/fasted variability It is known that the bioavailability of many products is influenced by interaction with food.
By reducing the fed/fasted variability, drug levels are more predictable. Furthermore, patient compliance will improve, as patients will no longer have to take their medication in connection with meals. LifeCycle Pharma's Melt Dose technology has shown the ability to develop formulations that eliminate or reduce the fed/fasted effect. Reduction in peak to trough ratio Drugs often exhibit high peak and low trough plasma levels. This may severely affect the clinical profile of the compound, since significant side effects may be induced at peak levels, while trough levels may diminish clinical efficacy. This pharmacokinetic problem can be overcome by the development of a controlled-release formulation.
LifeCycle Pharma has developed a unique technology that results in increased bioavailability in conjunction with a controlled- or modified-release formulation.